Immunohistochemical Analysis of Nicotinamide Phosphoribosyltransferase Expression in Gastric and Esophageal Adenocarcinoma (AEG)

Immunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse Trend

Background: Two of the Wnt signaling pathway target genes, tumor necrosis factor receptor family member (TROY) and leucine-rich G-protein coupled receptor (LGR5), are involved in the generation and maintenance of gastrointestinal epithelium. A negative modulatory role has recently been assigned to TROY, in this pathway. Here, we have examined their simultaneous expression in gastric carcinogene...

Immunohistochemical expression of p63 in esophageal Barrett's adenocarcinoma.

p63, which has recently been identified as a member of the p53 gene family, plays many important roles in human tissue functions. We examined p63 expression patterns in esophageal Barrett's adenocarcinoma, including early-stage cancers, as well as its clinicopathological significance. Immunoreactivity for p63 was detected in 45.8% (11/24) of the adenocarcinomas; all cases were focally positive....

Prevalence of p21 immunohistochemical expression in esophageal adenocarcinoma.

BACKGROUND In western societies, the prevalence of adenocarcinoma of the gastroesophageal junction has increased in recent years. It is commonly accepted today that esophageal adenocarcinoma develops from a premalignant lesion: Barrett's esophagus. This type of carcinoma is hardly diagnosed at early stages, which results in significant mortality. Molecular biology studies have shown that most m...

Nicotinamide Phosphoribosyltransferase in Sepsis

The word sepsis was derived from the Greek word: sêpsis, which means the state of putrefaction or decay. Sepsis is a potentially deadly medical condition that is characterized by a whole-body inflammatory state, called a systemic inflammatory response syndrome, and the presence of a known or suspected infection. The more critical subsets of sepsis are severe sepsis with acute organ dysfunction,...

Nicotinamide Phosphoribosyltransferase Inhibitors